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Polypharmacology in drug discovery

Polypharmacology in drug discovery

Name: Polypharmacology in drug discovery

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Language: English

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Drug discovery and development is a complex and expensive process [1,2]. The philosophy of drug design has been transformed from “one drug one target” to “one drug multiple targets”, coined as polypharmacology []. Polypharmacology is emerging as the next paradigm of drug discovery [7,]. Introduction - Current Technologies and - Challenges for - Expert commentary. Polypharmacology in Drug Discovery: A Review from Systems Pharmacology Perspective. Zhang W, Bai Y, Wang Y(1), Xiao W(2). Author information: BACKGROUND: The complexity of diseases has led to recent interest in polypharmacology, which suggests that many effective drugs specially modulate multiple targets. 28 Feb Polypharmacology in Drug Discovery presents an overview of the various facets of polypharmacology and how it can be applied as an.

28 Feb Extending drug discovery opportunities beyond the "one drug, one target" philosophy, a polypharmacological approach to the treatment of. 19 Jun At present, the legendary magic bullet, i.e., a drug with high potency and selectivity toward a specific biological target, shares the spotlight with an emerging and alternative polypharmacology approach. Polypharmacology suggests that more effective drugs can be developed by specifically modulating multiple targets. 13 Dec Polypharmacology involves the pharmaceutical compounds that exert of research for drug discovery in the future, due to the projected ability.

Polypharmacology remains one of the major challenges in drug development, and it opens novel avenues to rationally design the next generation of more. Polypharmacology is the design or use of pharmaceutical agents that act on multiple targets or Polypharmacology remains to be one of the major challenges in drug development, and it opens novel avenues to rationally design next. Request Full-text (PDF) | Polypharmacology in Drug Discovery. tions for future drug development and repurposing in the context of polypharmacology. Keywords: Shotgun drug discovery, virtual screening, computational. Today, polypharmacology is recognized as a new valuable opportunity for drug discovery and development. It is now well established that drug molecules.

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